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System Integrity Protection (ISP) should be on

System Integrity Protection is a security technology in OS X El Capitan and later that’s designed to help prevent potentially malicious software from modifying protected files and folders on your Mac. System Integrity Protection restricts the root user account and limits the actions that the root user can perform on protected parts of the Mac operating system.

Further reading: https://support.apple.com/en-us/HT204899

How to fix it

macOS 10.11 – 14

  1. Boot to Recovery OS by restarting your machine and holding down the Command and R keys at startup.

  2. Launch Terminal from the Utilities menu.

  3. Enter the following command:

    Terminal command
    csrutil enable

  4. Then restart you Mac again and run SimpleumCheck to check this again.